The protective effects of Aduola Fuzhenglin on the heart injury induced by microwave exposure in rats / 中华劳动卫生职业病杂志
Zhonghua laodong weisheng zhiyebing zazhi
; Zhonghua laodong weisheng zhiyebing zazhi;(12): 367-370, 2011.
Article
en Zh
| WPRIM
| ID: wpr-272598
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effects of AduoLa Fuzhenglin(ADL) on the heart injury induced by microwave exposure in rats.</p><p><b>METHODS</b>One hundred forty male Wistar rats were divided randomly into 5 groups: control, microwave radiation, 0.75 g x kg(-1) d(-1) ADL, 1.50 g x kg(-1) d(-1) ADL and 3.00 g x kg(-1) d(-1) ADL pretreatment groups. Rats in three ADL pretreatment groups were administrated by ADL per day for 2w then exposed to 30 mW/cm2 microwaves for 15 min. The left ventricle blood of rats was obtained at 7 d and 14 d after exposure to microwaves, and the blood Ca2+, AST and CK were detected with Coulter automatic biochemical analyzer, then the histological changes and ultrastructure of heart were observed under light and electron microscopes.</p><p><b>RESULTS</b>At 7 d and 14 d after exposure to microwaves, the blood Ca2+, AST and CK concentrations significantly increased (P<0.05 or P<0.01) as compared with controls; Heart muscle fibers showed wavilness, endotheliocyte karyopyknosis, anachromasis; The mitochondria swelling and cavitation, intercalary dies blurred in radiation groups. The changes in 0.75 g x kg(-1) d(-1) ADL pretreatment group were similar to the radiation group, but in 1.50 g x kg(-1)d(-1) and 3.00 g x kg(-1) d(-1) ADL pretreatment groups, above indexes of rats significantly reduced as compared with microwaves group (P<0.05); also the blood Ca2+, AST, CK contents were significantly lower than those in microwave group (P<0.05); The heart showed a tendency to improve.</p><p><b>CONCLUSION</b>Microwave radiation (30 mW/cm2) can cause the blood Ca2+, AST and CK turbulence, and heart injury in the histology and ultrastructure; ADL at the dosages of 1.50 g x kg(-1) d(-1) and 3.00 g x kg(-1) d(-1) has a protective effects on the heart injury induced by microwave in rats.</p>
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Base de datos:
WPRIM
Asunto principal:
Patología
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Farmacología
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Aspartato Aminotransferasas
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Efectos de la Radiación
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Sangre
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Medicamentos Herbarios Chinos
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Calcio
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Ratas Wistar
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Creatina Quinasa
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Corazón
Límite:
Animals
Idioma:
Zh
Revista:
Zhonghua laodong weisheng zhiyebing zazhi
Año:
2011
Tipo del documento:
Article