A study on the percutaneous penetration of artesunate from various reservoir vehicles / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 662-665, 2002.
Article
en Zh
| WPRIM
| ID: wpr-271813
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the main factors which affect the percutaneous penetration of artesunate and provide efficient data for the artesunate transdermal delivery system.</p><p><b>METHOD</b>Transdermal speed constant and accumulative amount of 12 hours were used for the estimations of various reservior vehicles, and the supplement orthodox design was used to study the effect of pH, various proportion of IPA/Water/IPM, and drug concentration.</p><p><b>RESULT</b>Drug concentration and pH were the main factors which affected the percutaneous penetration of artesunate.</p><p><b>CONCLUSION</b>The suitable reservior vehicle can prompt the percutaneous penetration of artesunate, and artesunate TTS will be made with further studies.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Sesquiterpenos
/
Absorción Cutánea
/
Administración Cutánea
/
Portadores de Fármacos
/
Farmacocinética
/
Sistemas de Liberación de Medicamentos
/
2-Propanol
/
Artemisininas
/
Concentración de Iones de Hidrógeno
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2002
Tipo del documento:
Article