Multivariate analysis of recurrence in T1 bladder transitional cell carcinoma / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 475-477, 2003.
Article
en Zh
| WPRIM
| ID: wpr-271100
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the prognostic value of some clinicopathologic indexes and biologic tumor markers in predicting recurrence in T1 transitional cell carcinoma (TCC) of the bladder.</p><p><b>METHODS</b>The expressions of p53, E-cadherin and VEGF of 75 patients with T1 primary bladder TCC were detected by streptabitin peroxidase (SP) immunohistochemical methods. The effects of clinicopathologic indexes and biologic tumor markers on recurrence were assessed by Kaplan-Meier and Cox proportional hazards model.</p><p><b>RESULTS</b>The 1-, 3-, and 5-year recurrence- free survival rates were 68.0%, 45.3% and 20.9%. In Kaplan-Meier analysis, tumor mutifocality and the expression of p53, E-cadherin and VEGF were associated with recurrence. In multivariate analysis, the independent recurrence variables were tumor mutifocality, the expression of p53 and E-cadherin.</p><p><b>CONCLUSION</b>Tumor mutifocality and the abnormal expression of p53 and E-cadherin are the variables that independently predict recurrence in T1 transitional cell carcinoma of the bladder.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias de la Vejiga Urinaria
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Carcinoma de Células Transicionales
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Cadherinas
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Análisis Multivariante
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Tasa de Supervivencia
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Mortalidad
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Proteína p53 Supresora de Tumor
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Factor A de Crecimiento Endotelial Vascular
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Recurrencia Local de Neoplasia
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Estadificación de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2003
Tipo del documento:
Article