Preparation of a biodegradable drug-eluting stent in myocardium channel / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 578-582, 2008.
Article
en Zh
| WPRIM
| ID: wpr-270645
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare a biodegradable drug-eluting stent in myocardium channel and evaluate its effect on myocardium channel after transmyocardial revascularization (TMR).</p><p><b>METHODS</b>A biodegradable drug-eluting stent was prepared using poly (epsilon-caprolactone) (PCL), bovine serum albumin (BSA), and poly (D, L-lactide-co-glycolide) (PLGA) as material of stent, model protein drug, and drug carrier respectively. The amount of BSA in stent and in vitro released BSA of stent were determined by the Coomassie brilliant blue assay. The mechanical strength of stent was tested by universal material testing machines. The material and structure of stent was characterized by nuclear magnetic resonance spectroscopy. The effect of stent on myocardium channel after TMR was evaluated in vivo by a standard animal model of chronic myocardial ischemia in miniswine.</p><p><b>RESULTS</b>The stent could carry 13.1 microg BSA per mg of stent and the stent could release about 95% of BSA after 30 days. The stent diminished 80% of initial scale under the stress of 1.7 Mpa. It also kept the myocardium channel patency after TMR.</p><p><b>CONCLUSIONS</b>A biodegradable drug-eluting stent in myocardium channel was successfully prepared. It can sustain the pressure from the heart and achieve the controlled release of drug. The stent can ensure the myocardium channel patency after TMR.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Cirugía General
/
Porcinos
/
Porcinos Enanos
/
Materiales Biocompatibles
/
Prótesis Vascular
/
Caproatos
/
Distribución Aleatoria
/
Química
/
Sistemas de Liberación de Medicamentos
/
Isquemia Miocárdica
Tipo de estudio:
Clinical_trials
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2008
Tipo del documento:
Article