HERG K+ channel, the target of anti-arrhythmias drugs / 药学学报
Acta Pharmaceutica Sinica
; (12): 687-691, 2007.
Article
en Zh
| WPRIM
| ID: wpr-268595
Biblioteca responsable:
WPRO
ABSTRACT
Rapidly activating component of delayed rectifier potassium current (I(Kr)) plays a key role in the repolarization phase of cardiac action potential. Human ether-a-go-go-related gene (HERG) encodes the alpha subunit of this potassium channel. Mutations of HERG gene induce genetic long QT syndrome (LQTS). Furthermore, I(Kr)/HERG is the target of some drugs which may cause cardiac QT interval prolongation. Some other drugs with different chemical structures also may block the channel and prolong QT interval, which even developed into acquired arrhythmias. This review summarized the recent progress of structure, gating mechanisms and functions of I(Kr)/HERG channel, I(Kr)/HERG related arrhythmias, interaction between K+ channel and drugs, and strategies of grading-up the I(Kr)/HERG target.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Arritmias Cardíacas
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Síndrome de QT Prolongado
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Activación del Canal Iónico
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Química
/
Bloqueadores de los Canales de Potasio
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Usos Terapéuticos
/
Quimioterapia
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Canales de Potasio Éter-A-Go-Go
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Genética
Límite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2007
Tipo del documento:
Article