Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 83-86, 2010.
Article
en Zh
| WPRIM
| ID: wpr-267436
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the association between methylthioadenosine phosphorylase (MTAP) gene single nucleotide polymorphisms (SNP) and myocardial infarction (MI) in the Chinese Han ethnicity. Methods 432 patients suffered from myocardial infarction and 430 controls were involved for case and control groups, respectively. Nine tag SNPs in MTAP gene were selected and genotyped. Results We found no significant association of selected tag SNPs with MI in all of the samples. However, in stratified analysis, significant association was observed at rs7027989 in male subjects. The risk of MI increased by 26% (P=0.005) for male subjects of minor allele carriers in a dominant model. The increased risk of MI at rs7027989 remained significant after adjusting for confounding factors. Conclusion MTAP gene might be involved in the etiology of MI in Chinese Han ethnicity.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Año:
2010
Tipo del documento:
Article