Pachymic acid, a novel compound for anti-rejection: effect in rats following cardiac allograft transplantation / 中华医学杂志(英文版)
Chin. med. j
; Chin. med. j;(24): 2898-2902, 2009.
Article
en En
| WPRIM
| ID: wpr-266019
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Pachymic acid (PA), a natural triterpenoid, is known to significantly reduce cell proliferation and induce apoptosis in vitro through initiation of mitochondria dysfunction. However, its effect on immune cells and anti-rejection following organ transplantation remains unknown.</p><p><b>METHODS</b>In this study, we investigated PA as a treatment to control acute rejection occurred in rats which had accepted cardiac transplantation. We measured apoptosis of peripheral blood lymphocyte (PBLs), and CD4(+) lymphocyte, as well as the number of CD4(+) and CD8(+) lymphocytes and the effect of PA on acute rejection in rats 7 days after cardiac transplantation.</p><p><b>RESULTS</b>PA treatment might decrease allograft rejection, protect PBLs from apoptosis, and reduce the percentage of CD8(+) lymphocyte. PA neither regulated the number nor the apoptosis rate of CD4(+) lymphocyte.</p><p><b>CONCLUSIONS</b>Our findings indicated that PA has an anti-apoptotic effect acting on PBLs through a novel mechanism involving stabilization of the PBLs mitochondrial transmembrane potential, an anti-rejection effect in rats after cardiac transplantation and an inhibiting effect to CD8(+) lymphocyte.</p>
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1
Base de datos:
WPRIM
Asunto principal:
Trasplante Homólogo
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Triterpenos
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Linfocitos
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Trasplante de Corazón
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Ratas Wistar
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Ratas Sprague-Dawley
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Apoptosis
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Usos Terapéuticos
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Quimioterapia
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Potencial de la Membrana Mitocondrial
Límite:
Animals
Idioma:
En
Revista:
Chin. med. j
Año:
2009
Tipo del documento:
Article