Cardiac Involvement in Patients with Duchenne Muscular Dystrophy
Journal of the Korean Society of Echocardiography
; : 152-158, 2005.
Article
en Ko
| WPRIM
| ID: wpr-26479
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Cardiac involvement in Duchenne muscular dystrophy (DMD) is common, but usually latent without symptoms or signs in the initial period of disease. This study investigated the incidence and predictor of cardiac involvement in DMD patients. METHOD: From January 2000 to June 2005, we enrolled 45 patients with DMD (aged 20.2+/-3.0 years) who admitted to the Yongdong Severance Hospital. Electrocardiography and transthoracic echocardiography was done to evaluate the cardiac function. RESULT: Electrocardiographic abnormalities were present in 80.1% of patients. Sinus tachycardia was most common (50%). LVEF was decreased (46.7+/-13.8%), and 56% of the patients had diastolic dysfunction. Patients with pulmonary involvement were older (20.7+/-3.8 vs 17.6+/-2.8 years, p=0.028), and patients with reduced LVEF (<50%) had longer duration of disease (11.4+/-4.4 vs 14.3+/-2.4 years, p=0.04). However, on multivariate analysis, age, duration of disease, pulmonary involvement, dyspnea symptom, electrocardiographic abnormality was not an independent predictor for LV systolic dysfunction in adolescent and adult patients with DMD. CONCLUSION: Cardiac involvement in adolescent and adult patients with DMD was frequently observed independent of age, duration of disease, pulmonary involvement, and dyspnea symptom. Therefore, more active cardiac investigation is required in patients with DMD, even without clinical suspicion.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Taquicardia Sinusal
/
Ecocardiografía
/
Incidencia
/
Análisis Multivariante
/
Distrofia Muscular de Duchenne
/
Disnea
/
Electrocardiografía
/
Enfermedades Pulmonares
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Humans
Idioma:
Ko
Revista:
Journal of the Korean Society of Echocardiography
Año:
2005
Tipo del documento:
Article