Effects of pomegranate tannins on experimental gastric damages / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 1290-1294, 2009.
Article
en Zh
| WPRIM
| ID: wpr-263047
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the antiulcer effects of pomegranate tannins in animal models.</p><p><b>METHOD</b>Gastric ulcer models were established by pylorus ligation, intragastric absolute ethanol, and water-immersion stress, respectively. The ulcer index, the contents of nitric oxide (NO) and malondialdehyde (MDA), the activities of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) from gastric mucosa of rats, the gastric juice volume, free acidity, total acidity,total acid output, the pepsin activity, the amount of adherent mucus and free mucus were measured, respectively.</p><p><b>RESULT</b>Pomegranate tannins (500, 150, 50 mg x kg(-1)) significantly inhibited ulcerative formation induced by both water immersion stress and pylorus ligation, obviously decreased the gastric mucosa damages induced by intragastric absolute ethanol, in dose-dependent manner. Pomegranate tannins significantly inhibited absolute alcohol-induced elevation of MDA as well as decreasing of NO level, and activities of both SOD and GHS-PX from gastric mucosa. Pomegranate tannins significantly increased the secretion of adherent mucus and free mucus, but did not affect elevation of the free acidity, total acidity, and total acid output, gastric juice volume, gastric pepsin activity induced by pylorus ligation.</p><p><b>CONCLUSION</b>Pomegranate tannins play a protective role against gastric ulcer. Its antiulcer effect is related to increasing secretion of adherent mucus and free mucus from the stomach wall, which may inhibit generation of oxygen-derived free radicals, and decrease the consumption of GSH-PX and SOD, and maintain content of NO at normal level.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Píloro
/
Úlcera Gástrica
/
Taninos
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Extractos Vegetales
/
Química
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Ratas Sprague-Dawley
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Lythraceae
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Usos Terapéuticos
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Modelos Animales de Enfermedad
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Etanol
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2009
Tipo del documento:
Article