Correlation of stromal cell derived factor-1 with angiogenesis and cell apoptosis in myelodysplastic syndromes / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1438-1442, 2011.
Article
en Zh
| WPRIM
| ID: wpr-261852
Biblioteca responsable:
WPRO
ABSTRACT
The study was aimed to investigate the expression of stromal cell derived factor (SDF-1) in bone marrow (BM) and its relation with apoptosis of BM CD34(+) cell and angiogenesis in myelodysplastic syndrome (MDS). 40 patients with MDS were divided into low-risk group and high-risk group according to IPSS score system. BM samples were collected. SDF-1 levels, the apoptosis of CD34(+) cells and microvessel density (MVD) of BM were detected by ELISA, flow cytometry and immunochemistry, respectively. The results showed that the SDF-1 level in MDS patients was significantly higher than that in normal controls(p < 0.05), and SDF-1 level in low-risk group was significantly higher than that in high-risk group. Apoptosis of CD34(+) cells significantly increased in low-risk group compared with other groups (p < 0.05). MVD in BM biopsy significantly increased in high-risk MDS group (p < 0.05), compared with low-risk MDS group which also had higher MVD than the control group (p < 0.05). Positive correlation was found between apoptosis of CD34(+) cells and SDF-1 levels in low-risk group, and SDF-1 level and MVD in high-risk group. It is concluded that the expression of SDF-1, apoptosis of BM CD34(+) cells and MVD were significantly abnormal in MDS patients, especially in different risk group, suggesting that SDF-1 level is related to cell apoptosis and angiogenesis.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Médula Ósea
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Síndromes Mielodisplásicos
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Apoptosis
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Quimiocina CXCL12
/
Metabolismo
/
Neovascularización Patológica
Límite:
Adolescent
/
Adult
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Aged
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2011
Tipo del documento:
Article