Cytokine gene polymorphisms in Chinese patients with type I autoimmune hepatitis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 296-298, 2004.
Article
en Zh
| WPRIM
| ID: wpr-260024
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the role of Tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) gene polymorphisms in susceptibility to type I autoimmune hepatitis (AIH).</p><p><b>METHODS</b>We detected 2 polymorphisms in TNF-alpha promoter gene at positions -238 and -308 and 3 polymorphic sites in IL-10 gene promoter at positions -1082, -819, -592 by polymerase chain reaction and dot blot with probes in the patients with 32 type I AIH and 48 health controls.</p><p><b>RESULTS</b>Genotypes associated with guanine to adenine substitution at position -308 of TNF-alpha promoter gene occurred more commonly in the patients than in health controls (53.1% vs. 27.1%, RR = 3.05, P < 0.01). There is no significant difference in polymorphisms of TNF-alpha gene at position -238 and 3 polymorphic sites in IL-10 promoter gene between patients and health controls.</p><p><b>CONCLUSION</b>Genotypes associated with guanine to adenine substitution at position -308 of TNF-alpha promoter gene (TNF-308A) may involve in the pathogenesis of type I AIH</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
/
Regiones Promotoras Genéticas
/
Factor de Necrosis Tumoral alfa
/
Interleucina-10
/
Hepatitis Autoinmune
/
Alergia e Inmunología
/
Genética
Límite:
Adult
/
Aged
/
Female
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Año:
2004
Tipo del documento:
Article