Design, synthesis and biological evaluation of novel diaryl ethers bearing a pyrimidine motif as human Pin1 inhibitors / 药学学报
Yao Xue Xue Bao
; (12): 1266-1272, 2013.
Article
en Zh
| WPRIM
| ID: wpr-259484
Biblioteca responsable:
WPRO
ABSTRACT
Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) belongs to peptidyl-prolyl cis-trans isomerase (PPIase) and is a novel promising anticancer target. Based on the lead structure of benzophenone, a series of novel diarylether derivatives containing a pyrimidine ring were designed and synthesized. The inhibitory activities on Pin1 of compounds 5a-5d and 6a-6i were evaluated by a protease-coupled enzyme assay. Of all the evaluated compounds, 6 compounds displayed inhibitory activities. Molecular docking was performed using FlexX algorithm to explore the binding mode of the active molecules.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Pirimidinas
/
Relación Estructura-Actividad
/
Diseño de Fármacos
/
Estructura Molecular
/
Química
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Isomerasa de Peptidilprolil
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Concentración 50 Inhibidora
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Inhibidores Enzimáticos
/
Éteres
Límite:
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2013
Tipo del documento:
Article