Occult lymph node metastasis in the middle and lower third rectal cancer after neoadjuvant radiotherapy / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 189-192, 2010.
Article
en Zh
| WPRIM
| ID: wpr-259312
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the occult lymph node metastasis in the middle and lower third rectal cancer after neoadjuvant radiotherapy.</p><p><b>METHODS</b>From June 2003 to December 2006, 74 rectal cancer patients received neoadjuvant radiotherapy (30 Gy/10 f/2 w, CACA-CRC-001) and underwent total mesorectal excision (TME) two weeks later. Fat clearance technique was used in all the samples. Occult lymph node metastasis was detected in the mesorectum using the anti-CK antibody.</p><p><b>RESULTS</b>In total 1883 retrieved lymph nodes, 172 metastasis lymph nodes were harvested by HE examination with the mean diameter [(4.9+/-2.6) mm] being larger than that (2.7+/-1.4) mm of the 1711 negative nodes (P<0.01). In HE negative nodes, occult metastasis was found in 40 lymph nodes (2.33%) from 24 patients. Most of these nodes were less than 5 mm (90.0%) with a mean diameter of (3.2+/-1.2)mm, smaller than those of HE-positive metastasis nodes (P<0.01). Occult metastasis was found in 23.1% (9/39) of HE-negative patients. Occult metastasis incidence was higher in patients with HE-positive nodes (42.8%,P<0.01). No correlation of lymph node occult metastasis with tumor differentiation, age, or surgical procedures was found. There was no significant difference in recurrence-free survival between ypN(0) patients with and without occult metastasis (P=0.157).</p><p><b>CONCLUSION</b>It is not necessary to include occult lymph node metastasis in the TNM staging in patients with ypN(0) rectal cancer.</p>
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Base de datos:
WPRIM
Asunto principal:
Patología
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Radioterapia
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Neoplasias del Recto
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Radioterapia Adyuvante
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Terapia Neoadyuvante
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Ganglios Linfáticos
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Metástasis Linfática
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Estadificación de Neoplasias
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2010
Tipo del documento:
Article