Sperm DNA damage and sperm-nucleoprotein transition correlate to acrosin activity and seminal parameters / 中华男科学杂志
National Journal of Andrology
; (12): 925-929, 2012.
Article
en Zh
| WPRIM
| ID: wpr-256981
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters.</p><p><b>METHODS</b>We collected 535 semen samples, assessed sperm DNA damage by sperm chromatin dispersion test, and analyzed the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters according to the WHO criteria.</p><p><b>RESULTS</b>Statistically significant differences were observed in sperm DNA damage among sperm-nucleoprotein transition, acrosin activity, sperm concentration and the percentage of grade a + b sperm (P < 0.01). Sperm DNA damage was positively correlated with age, sperm-nucleoprotein transition, sperm concentration and the percentage of grade d sperm (P < 0.01 or P < 0.05), but negatively correlated with acrosin activity (P < 0.001). Stepwise linear regression analysis demonstrated that age, sperm concentration, the percentage of grade d sperm, sperm-nucleoprotein transition and acrosin activity were independent variables related to the DNA fragmentation index (DFI). The abnormality rates of sperm-nucleoprotein transition, acrosin activity, sperm concentration and graded a + b sperm were significantly higher in the sperm DNA damage group (DFI > or = 30%) than in the normal control (DFI < 30%) (P < 0.01).</p><p><b>CONCLUSION</b>Sperm DNA damage is closely related with sperm-nucleoprotein transition, acrosin activity and seminal parameters, which may become another important independent parameter for the evaluation of sperm quality.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Recuento de Espermatozoides
/
Motilidad Espermática
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Espermatozoides
/
Daño del ADN
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Acrosina
/
Cromatina
/
Fragmentación del ADN
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Genética
/
Infertilidad Masculina
/
Metabolismo
Límite:
Adult
/
Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2012
Tipo del documento:
Article