Effects of rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 18-21, 2016.
Article
en Zh
| WPRIM
| ID: wpr-254966
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The present study investigated the effects of rapamycin on Aβ1-42-induced deficits in working memory and synaptic plasticity.</p><p><b>METHODS</b>After bilateral hippocampal injection of Aβ1-42 and rapamycinin rats, spontaneous alternation in Y-maze and in vivo hippocampal long-term potentiation (LTP) of rats were recorded. All data were analized by two-way repeated measures analysis of variance (ANOVA).</p><p><b>RESULTS</b>(Hippocampal injection of Aβ1-42 alone impaired working memory of rats; (2) Rapamycin did not affect working memory of rats, but alleviated Aβ1-42-induced working memory deficits, compared with Aβ1-42 alone group; (Aβ1-42 remarkably suppressed in vivo hippocampal LTP of fEPSPs in the CA1 region; (4) Pretreatment with rapamycin prevented Aβ1-42-induced suppression of LTP.</p><p><b>CONCLUSION</b>These data indicates that rapamycin could protect against Aβ1-42-induced impairments in working memory and synaptic plasticity in rats.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fragmentos de Péptidos
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Farmacología
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Péptidos beta-Amiloides
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Potenciación a Largo Plazo
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Aprendizaje por Laberinto
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Sirolimus
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Hipocampo
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Memoria a Corto Plazo
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Plasticidad Neuronal
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2016
Tipo del documento:
Article