Efficacy of inhaled nitric oxide in premature infants with hypoxic respiratory failure / 中国当代儿科杂志
Zhongguo dangdai erke zazhi
; Zhongguo dangdai erke zazhi;(12): 805-809, 2014.
Article
en Zh
| WPRIM
| ID: wpr-254194
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the safety and efficacy of low-concentration inhaled nitric oxide (NO) in the treatment of hypoxic respiratory failure (HRF) among premature infants.</p><p><b>METHODS</b>Sixty premature infants (gestational age ≤ 34 weeks) with HRF were randomized into NO and control groups between 2012 and 2013, with 30 cases in each group. Both groups received nasal continuous positive airway pressure (nCPAP) or mechanical ventilation. NO inhalation was continued for at least 7 days or until weaning in the NO group. The general conditions, blood gas results, complications, and clinical outcomes of the two groups were analyzed.</p><p><b>RESULTS</b>The NO group showed significantly more improvement in blood gas results than the control group after 12 hours of treatment (P<0.05). After that, the change in oxygenation status over time showed no significant difference between the two groups (P>0.05). There were no significant differences in total time of assisted ventilation and duration of oxygen therapy between the two groups (P>0.05). The incidence of bronchopulmonary dysplasia (BPD), patent ductus arteriosus, necrotizing enterocolitis, retinopathy of prematurity, and pneumothorax in infants showed no significant differences between the NO and control groups (P>0.05), but the incidence of IVH and mortality were significantly lower in the NO group than in the control group (7% vs 17%, P<0.05; 3% vs 13%, P<0.05).</p><p><b>CONCLUSIONS</b>NO inhalation may improve oxygenation status and reduce the mortality in premature infants with HRF, but it cannot reduce the incidence of BPD and the total time of mechanical ventilation or nCPAP and duration of oxygen therapy. NO therapy may have a brain-protective effect for premature infants with HRF and does not increase clinical complications.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Insuficiencia Respiratoria
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Sangre
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Análisis de los Gases de la Sangre
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Administración por Inhalación
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Displasia Broncopulmonar
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Recien Nacido Prematuro
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Epidemiología
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Incidencia
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Quimioterapia
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Hipoxia
Tipo de estudio:
Clinical_trials
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Incidence_studies
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Prognostic_studies
Límite:
Humans
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Newborn
Idioma:
Zh
Revista:
Zhongguo dangdai erke zazhi
Año:
2014
Tipo del documento:
Article