Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation / 药学学报
Acta Pharmaceutica Sinica
; (12): 916-919, 2005.
Article
en Zh
| WPRIM
| ID: wpr-253541
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on thrombosis and platelet aggregation, and to explore its mechanism of action.</p><p><b>METHODS</b>Thrombosis was observed with arteriovenous shunt thrombus model in rat; platelet aggregation was determined by Born's method; ultrastructure of platelet was observed by transmission electron microscope; TXB2 or 6-keto-PGF1alpha levels were assessed by radioimmunoassay; and NO was determined by colorimetric method.</p><p><b>RESULTS</b>PAMD dose-dependently inhibited experimental thrombus formation, platelet aggregation induced by ADP, AA and THR in vivo and ultrastructure changes stimulated by THR; PAMD increased the generation of 6-keto-PGF1alpha in thoracic aortae and NO level in plasma; and had no influence on TXB2 release (P > 0.05).</p><p><b>CONCLUSION</b>PAMD inhibited thrombosis and platelet aggregation, and its mechanism might be due to the increase of PGI2 and NO level.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Aorta Torácica
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Farmacología
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Plantas Medicinales
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Trombosis
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Tromboxano B2
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Sangre
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Plaquetas
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6-Cetoprostaglandina F1 alfa
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Química
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Agregación Plaquetaria
Límite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2005
Tipo del documento:
Article