MGMT expression and its relationship with efficacy of chemotherapy and prognosis in patients with non-small cell lung cancer / 中国肺癌杂志
Zhongguo fei'ai zazhi (Online)
; Zhongguo fei'ai zazhi (Online);(12): 63-66, 2003.
Article
en Zh
| WPRIM
| ID: wpr-252378
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>To study the expression of MGMT and its relationship with efficacy of chemotherapy and prognosis in patients with non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>MGMT was detected in 128 NSCLC tissues and 10 normal pulmonary tissues by immunohistochemistry. According to the level of MGMT , 128 patients with NSCLC were divided into the group Mer- with negative MGMT expression and the group Mer+ with positive MGMT expression.</p><p><b>RESULTS</b>MGMT positively expressed in 61 of 128 patients with NSCLC (47.66%), but none of normal group. No significant relationship was found among MGMT expression and TNM stages, lymph node metastasis and histological classification of the cancer. However, the mean survival periods and survival rates in group Mer- were significantly higher than those of group Mer+ (P < 0.01 , P < 0.05). In 45 evaluable patients, total response rates were 42.86% and 4.17% in Mer- and Mer+ patients respectively (P < 0.001); and there were remarkably longer mean survival periods and higher survival rates in Mer- patients than those in Mer+ patients (P < 0.01, P < 0.05).</p><p><b>CONCLUSIONS</b>Expression of MGMT may be helpful to predict efficacy of chemotherapy and prognosis in patients with NSCLC.</p>
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1
Base de datos:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Zhongguo fei'ai zazhi (Online)
Año:
2003
Tipo del documento:
Article