PI3K/AKT/mTOR Pathway and Pediatric T Acute Lymphoblastic Leukemia-Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1269-1274, 2016.
Article
en Zh
| WPRIM
| ID: wpr-246777
Biblioteca responsable:
WPRO
ABSTRACT
The PI3K/Akt/mTOR signaling pathway plays a central role in cell growth, proliferation and survival in physiological conditions. This signal pathway is considered to be an innovative targeted therapy of cancer, and its abnormal activation has been proved to be related to T-cell acute lymphoblastic leukemia (T-ALL) .Despite improved treatment strategies, such as multi-drug combination, high-dose chemotherapy and all kinds of application and popularization of hematopoietic stem cell transplantation, children with drug resistance or relapse T-ALL are still rather worse and its overall outcome and prognosis are much poorer than the more common B-lineage ALL. Therefore, more effective and less cytotoxic treatment targeted strategies for leukemia greatly needed. This review focuses on the relationship between the PI3k/Akt/mTOR pathway and the pediatric T-ALL, so as to reveal the exact molecular mechanism of T-ALL and provide more directions for its treatment.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Transducción de Señal
/
Fosfatidilinositol 3-Quinasas
/
Proliferación Celular
/
Proteínas Proto-Oncogénicas c-akt
/
Leucemia-Linfoma Linfoblástico de Células T Precursoras
/
Serina-Treonina Quinasas TOR
Límite:
Child
/
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2016
Tipo del documento:
Article