Gene expression in patients with myelodysplastic syndrome / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 666-670, 2010.
Article
en Zh
| WPRIM
| ID: wpr-243290
Biblioteca responsable:
WPRO
ABSTRACT
This study was aimed to investigate the expression of c-FLIPL, c-FLIPS and DLK1 mRNA in the patients with myelodysplastic syndrome (MDS) and its clinical significance. The mRNA expression of c-FLIPL, c-FLIPS and DLK1 in bone marrow mononuclear cells (BMMNC) of 16 patients with MDS and 3 controls were detected by RT-PCR. The results indicated that the expression of DLK1 mRNA was up-regulated in MDS, including RA and RAEB, as compared with controls (p < 0.05). There was no significant difference in expression of DLK1 between RA and RAEB patients (p > 0.05); the expression of c-FLIPL mRNA both in RA and RAEB patients was higher than that in controls (p < 0.05). There was no significant difference in expression of c-FLIPL between RA and RAEB patients (p > 0.05); the expression of c-FLIPS mRNA was not significantly different between MDS patients and controls (p > 0.05), but its expression in RAEB patients was significantly higher as compared with RA patients and controls (p < 0.05). It is concluded that the mRNA expressions of DLK1, c-FLIPL and c-FLIPS in MDS patients are abnormal, some of which may be useful as an important indicator for the evaluation of development in MDS.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Síndromes Mielodisplásicos
/
ARN Mensajero
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Células de la Médula Ósea
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Estudios de Casos y Controles
/
Expresión Génica
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Péptidos y Proteínas de Señalización Intercelular
/
Proteína Reguladora de Apoptosis Similar a CASP8 y FADD
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Genética
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Proteínas de la Membrana
/
Metabolismo
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2010
Tipo del documento:
Article