Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type II as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 483-490, 2011.
Article
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| WPRIM
| ID: wpr-241570
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>The expression of genes encoding a number of pathogenetic pathways involved in colorectal cancer could potentially act as prognostic markers. Large prospective studies are required to establish their relevance to disease prognosis.</p><p><b>METHODS</b>We investigated the relevance of 19 markers in 790 patients enrolled in a large randomised trial of 5-fluorouracil using immunohistochemistry and chromogenic in situ hybridisation. The relationship between overall 10-year survival and marker status was assessed.</p><p><b>RESULTS</b>Minichromosome maintenance complex component 2 (MCM2) and cyclin A were significantly associated with overall survival. Elevated MCM2 expression was associated with a better prognosis (HR = 0.63, 95%CI: 0.46 - 0.86). Cyclin A expression above the median predicted an improved patient prognosis (HR = 0.71, 95%CI: 0.53 - 0.95). For mismatch repair deficiency and transforming growth factor β receptor type II (TGFBRII) overexpression there was a borderline association with a poorer prognosis (HR = 0.69, 95%CI: 0.46 - 1.04 and HR = 2.11, 95%CI: 1.02 - 4.40, respectively). No apparent associations were found for other markers.</p><p><b>CONCLUSION</b>This study identified cell proliferation and cyclin A expression as prognostic indicators of patient outcome in colorectal cancer.</p>
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Base de datos:
WPRIM
Asunto principal:
Fisiología
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Pronóstico
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Neoplasias Colorrectales
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Estudios Prospectivos
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Proteínas Serina-Treonina Quinasas
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Hibridación in Situ
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Receptores de Factores de Crecimiento Transformadores beta
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Antígeno Ki-67
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Ciclina A
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Análisis de Matrices Tisulares
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese Medical Journal
Año:
2011
Tipo del documento:
Article