Pharmacokinetics of beta-asarone in rats / 药学学报
Acta Pharmaceutica Sinica
; (12): 836-838, 2004.
Article
en Zh
| WPRIM
| ID: wpr-241388
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To study the pharmacokinetics of beta-asarone in rats.</p><p><b>METHODS</b>The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system.</p><p><b>RESULTS</b>The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum.</p><p><b>CONCLUSION</b>The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Plantas Medicinales
/
Encéfalo
/
Farmacocinética
/
Barrera Hematoencefálica
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Distribución Tisular
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Química
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Administración Oral
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Cromatografía Líquida de Alta Presión
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Ratas Sprague-Dawley
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Raíces de Plantas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2004
Tipo del documento:
Article