Factors influencing the progression-free survival time of prostate cancer patients after endocrine therapy / 中华男科学杂志
Zhonghua nankexue
; Zhonghua nankexue;(12): 801-805, 2009.
Article
en Zh
| WPRIM
| ID: wpr-241253
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The progression of prostate cancer (PCa) after endocrine therapy varies widely in different PCa patients. This study aims to analyze the factors that influence the progression-free survival time of PCa patients after endocrine therapy in an attempt to improve the prognosis of the disease.</p><p><b>METHODS</b>We reviewed the clinicopathological data of 116 cases of prostate cancer treated by endocrine therapy, analyzed the clinicopathological factors that influence the progression-free survival time of PCa patients using univariate (log-rank test) and multivariate Cox proportional hazard models, and investigated the correlation among these factors by Spearman rank correlation analysis.</p><p><b>RESULTS</b>In the stepwise Cox proportional hazard model, the independent prognostic factors for PCa progression after endocrine therapy were found to be Gleason score (P < 0.01) and clinical stages (P < 0.01). The hazard of PCa progression after endocrine therapy increased 2.126 times that of the baseline for each unit of increase in Gleason score, and 6.625 times for each unit of increase in the clinical stage. The pretreatment PSA level was correlated with both clinical stages (P < 0.01) and Gleason score (P < 0.01).</p><p><b>CONCLUSION</b>Clinical stages and Gleason score were important factors that influenced the progression-free survival time after endocrine therapy in this cohort of PCa patients.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Pronóstico
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Próstata
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Neoplasias de la Próstata
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Terapéutica
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Modelos de Riesgos Proporcionales
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Mortalidad
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Supervivencia sin Enfermedad
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Estadificación de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Aged80
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua nankexue
Año:
2009
Tipo del documento:
Article