Danggui-shaoyao-san, a traditional Chinese medicine prescription, alleviates the orthodontic pain and inhibits neuronal and microglia activation / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 3630-3637, 2014.
Article
en En
| WPRIM
| ID: wpr-240716
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>The pain caused by orthodontic treatment has been considered as tough problems in orthodontic practice. Danggui-shaoyao-san (DSS) is a traditional Chinese medicine (TCM) prescription which has long been used for pain treatment and possesses antioxidative, cognitive enhancing and antidepressant effects. We raise the hypothesis that DSS exerts analgesic effect for orthodontic pain via inhibiting the activations of neuron and microglia.</p><p><b>METHODS</b>DSS was given twice a day from day 5 prior to experimental tooth movement (ETM). Directed face grooming and vacuous chewing movements (VCM) were evaluated. Immunofluorescent histochemistry and Western blot analysis were used to quantify the Iba-1 (microglia activation) and Fos (neuronal activation) expression levels in the trigeminal spinal nucleus caudalis (Vc).</p><p><b>RESULTS</b>ETM significantly increased directed face grooming and VCM which reached the peak at post-operative day (POD) 1 and gradually decreased to the baseline at POD 7. However, a drastic peak increase of Fos expression in Vc was observed at 4 hours and gradually decreased to baseline at POD 7; while the increased Iba-1 level reached the peak at POD 1 and gradually decreased to baseline at POD 7. Furthermore, pre-treatment with DSS significantly attenuated the ETM induced directed face grooming and VCM as well as the Fos and Iba-1 levels at POD 1.</p><p><b>CONCLUSION</b>Treatment with DSS had significant analgesic effects on ETM-induced pain, which was accompanied with inhibition of both neuronal and microglial activation.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Dolor
/
Fisiología
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Periodo Posoperatorio
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Técnicas de Movimiento Dental
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Medicamentos Herbarios Chinos
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Ratas Sprague-Dawley
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Microglía
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Usos Terapéuticos
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Quimioterapia
/
Cara
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Chinese Medical Journal
Año:
2014
Tipo del documento:
Article