Efficacy of Hushen Gujing (HSGJ) in preventing chronic allograft nephropathy in rats / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 1349-1352, 2005.
Article
en Zh
| WPRIM
| ID: wpr-239686
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of HSGJ on chronic allograft nephropathy (CAN) using standard rat model of CAN.</p><p><b>METHOD</b>Renal transplantation was performed with Fisher rats as donors and Lewis rats as recipients. All the recipients were randomly divided into control group and medication groups (high and low dosage of HSGJ, fed every other day). After 16 weeks of treatment, renal function and the histological alteration of CAN were measured. The expression of the TGFbeta1 mRNA in the allograft was evaluated by real-time PCR.</p><p><b>RESULT</b>The content of 24 h urine protein and the level of serum creatinine in the medication groups were significantly decreased (P < 0.01) as compared with control group, whereas the creatinine clearance was increased (P < 0.01). The degree of glomerular sclerosis and the Banff score of medication groups were lower than the control group respectively (P < 0.01), in consistent with decreased expression of the TGF 1mRNA.</p><p><b>CONCLUSION</b>HSGJ can prevent the chronic allograft nephropathy and the mechanism may be related with its influence on the expression of the TGFbeta1.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Ratas Endogámicas Lew
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Ratas Endogámicas F344
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Trasplante Homólogo
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Medicamentos Herbarios Chinos
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Distribución Aleatoria
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Enfermedad Crónica
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Trasplante de Riñón
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Usos Terapéuticos
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Quimioterapia
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Alergia e Inmunología
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2005
Tipo del documento:
Article