Advances in researches on polymorphonuclear neutrophil elastase in semen / 中华男科学杂志
National Journal of Andrology
; (12): 1023-1028, 2011.
Article
en Zh
| WPRIM
| ID: wpr-239038
Biblioteca responsable:
WPRO
ABSTRACT
Reproductive tract infection is one of the important factors of male reproduction. Polymorphonuclear neutrophil elastase (PMNE) in semen, as a marker of male reproductive tract inflammation, especially recessive infection, potentially affects male fertility. The concentration of PMNE in semen is correlated significantly not only with semen white blood cell count and seminal plasma ROS level, but also with the levels of other inflammation related cytokines, such as IL-6, IL-8, and TNF-alpha. Furthermore, PMNE has a negative impact on sperm quality by decreasing sperm motility, increasing the percentage of morphologically abnormal sperm and interfering with DNA integrity. PMNE inhibitors in semen can form a compound with PMNE, and the imbalanced proportions of the two may promote the development of chronic inflammation, and consequently lead to male infertility. At present, PMNE in semen is detected mainly by enzyme immunoassay, but this method still needs to be standardized, and the diagnostic standards to be unified.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Semen
/
Elastasa de Leucocito
Tipo de estudio:
Guideline
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2011
Tipo del documento:
Article