Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3444-3449, 2015.
Article
en Zh
| WPRIM
| ID: wpr-237691
Biblioteca responsable:
WPRO
ABSTRACT
Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Medicamentos Herbarios Chinos
/
Receptores de Esteroides
/
Expresión Génica
/
Evaluación Preclínica de Medicamentos
/
Genética
/
Metabolismo
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Article