Mutation of tet2 gene and malignant blood disease / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1096-1100, 2010.
Article
en Zh
| WPRIM
| ID: wpr-237587
Biblioteca responsable:
WPRO
ABSTRACT
Tet2 (the 2nd member of tet oncogene family) is a newly discovered antioncogene on the chromosome 4q24 of the patient with malignant myeloma, which has a potential for functional deletion. Recent studies demonstrated that tet2 mutation was found in polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis, systematic mastocytosis (SM), and myelodysplastic syndrome (MDS). However, a great number of perspective researches are still needed for exploring the role of tet2 in the pathogenesis of malignant blood diseases. In this review, the relation of tet2 mutation with myeloproliferative neoplasm, systemic mastocytosis, myelodysplastic syndrome, acute myeloid leukemia and other malignant blood diseases are summarized.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Síndromes Mielodisplásicos
/
Proteínas Proto-Oncogénicas
/
Proteínas de Unión al ADN
/
Genética
/
Enfermedades Hematológicas
/
Mutación
/
Trastornos Mieloproliferativos
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2010
Tipo del documento:
Article