Docetaxel in the treatment of advanced breast cancer / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 468-470, 2006.
Article
en Zh
| WPRIM
| ID: wpr-236914
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy, toxicity and safety of an new domestic docetaxel in the treatment of pretreated advanced breast cancer.</p><p><b>METHODS</b>Fourty-four breast cancer patients who had failed in first-line chemotherapy were included in this trial. They received docetaxel as the second-line chemotherapy. Docetaxel was administered alone at a dose of 70 mg/m2 every 3 weeks. The use of granulocyte colony-stimulating factor to prevent granulocytopenia was not permitted. The response rate and toxicity were evaluated by World Health Organization toxicity scale and performance status by Karnofsky scale.</p><p><b>RESULTS</b>Of the 41 evaluable patients, 4 achieved complete response and 14 partial remission, with a response rate and clinical benefit rate of 43.9% and 85.4%, respectively. Grade 3 or grade 4 neutropenia developed in 42.9%, alopecia in 7.1% and vomiting in 4.8% of these patients. Fluid retention was not observed in this series.</p><p><b>CONCLUSION</b>Three-week administration of docetaxel alone at a dose of 70 mg/m2 is effective and tolerable. It provides an alternative for the pretreated advanced breast cancer patients.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Vómitos
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Inducción de Remisión
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Neoplasias de la Mama
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Resultado del Tratamiento
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Taxoides
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Usos Terapéuticos
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Quimioterapia
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Alopecia
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Estadificación de Neoplasias
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2006
Tipo del documento:
Article