Experimental study on the PAR-1 expression around hemotoma following intracerebral hemorrhage in rats / 华中科技大学学报（医学）（英德文版）
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 266-268, 2004.
Article
en En
| WPRIM
| ID: wpr-236553
Biblioteca responsable:
WPRO
ABSTRACT
In order to explore the PAR-1 mRNA and protein expression around hemotoma following intracerebral hemorrhage and the relation between the PAR-1 expression and thrombin, collagenase VII was stereotaxically injected into right caudate nucleus in rats. The PAR-1 mRNA expression was detected by RT-PCR method and the PAR-1 protein expression by immunohistochemical method respectively. It was found that the PAR-1 mRNA and protein expression around hemotoma was increased at 6 h after intracerebral hemorrhage (P<0.05), peaked at 2 days (P<0.01), and then declined. The change pattern of the PAR-1 mRNA and protein expression was similar to that of intracerebral hemorrhage after thrombin intracerebral injection. The PAR-1 mRNA and protein expression in hirudin group showed no significant difference with control group. These results indicated that the PAR-1 mRNA and protein expression were markedly increased after intracerebral hemorrhage, which may be closely related to thrombin. Upregulation of the PAR-1 expression may involve in neurotoxic injury induced by thrombin.
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Base de datos:
WPRIM
Asunto principal:
Farmacología
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ARN Mensajero
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Trombina
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Distribución Aleatoria
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Hemorragia Cerebral
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Hirudinas
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Ratas Sprague-Dawley
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Receptor PAR-1
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Fibrinolíticos
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Genética
Límite:
Animals
Idioma:
En
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Año:
2004
Tipo del documento:
Article