Determination of the concentrations of interleukin-18 and other cytokines in the synovial fluid in patients with osteoarthritis / 南方医科大学学报
Journal of Southern Medical University
; (12): 729-731, 2009.
Article
en Zh
| WPRIM
| ID: wpr-233698
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the concentrations of interleukin-18 (IL-18), IL-6, IL-8, and prostaglandin E2 (PGE2) in the synovial fluid in patients with osteoarthritis (OA), and explore the role of IL-18 in the pathogenesis of OA.</p><p><b>METHODS</b>The synovial fluid was collected from 30 patients with knee OA, and the concentrations of IL-18 and the other cytokines were measured using enzyme-linked immunosorbent assay (ELISA). A linear regression was performed between IL-18 and the other cytokines.</p><p><b>RESULTS</b>The average IL-18 and PGE2 concentrations were 220-/+304 pg/ml and 89-/+104 pg/ml in the synovial fluid, respectively, and the two cytokines showed a positive correlation in the synovial fluid (r=0.628, P=0.001). The IL-18 concentration was also correlated to the concentrations of IL-6 (1200-/+1587 pg/ml, n=22; r=0.590, P=0.008) and IL-8 (5190-/+6024 pg/ml, n=9; r=0.776, P=0.014).</p><p><b>CONCLUSION</b>IL-18 can promote PGE2 production, which causes cartilage degradation in OA, thus therapies targeting this cytokine may prove an effective approach to early OA treatment.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoartritis
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Líquido Sinovial
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Dinoprostona
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Interleucina-18
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Metabolismo
Límite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Article