Drug discovery based on classic natural products / 药学学报
Acta Pharmaceutica Sinica
; (12): 11-18, 2009.
Article
en Zh
| WPRIM
| ID: wpr-232605
Biblioteca responsable:
WPRO
ABSTRACT
We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property. The strategy includes: to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Ácido Oleanólico
/
Farmacología
/
Triterpenos
/
Vinblastina
/
Berberina
/
Productos Biológicos
/
Camptotecina
/
Química
/
Fármacos Anti-VIH
/
Descubrimiento de Drogas
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Article