Association between ESR1 gene polymorphisms and haplotypes with schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 21-25, 2013.
Article
en Zh
| WPRIM
| ID: wpr-232213
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between single nucleotide polymorphisms (SNPs) and haplotypes of estrogen receptor 1 (ESR1) gene with schizophrenia.</p><p><b>METHODS</b>Three SNPs (rs2234693, rs9340799 and rs3798759) were determined in 333 schizophrenic patients and 315 healthy subjects with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Allelic and genotypic frequencies and particular haplotypes were compared between the two groups using Chi-square test.</p><p><b>RESULTS</b>The allelic and genotypic frequencies of rs2234693 and rs9340799 showed no significant difference between the two groups (P U+003E 0.05). However, a significant difference was detected in the frequencies of rs3798759 G allele and GG genotype between the two groups (P U+003C 0.01). Single factor analysis stratified by sex also found that frequencies of rs3798759 GG and TG genotypes and G allele were significantly higher in female schizophrenia patients compared with healthy females (P U+003C 0.05). Haplotypes C-A-G and C-G-G were more common in schizophrenia group (P U+003C 0.05).</p><p><b>CONCLUSION</b>polymorphisms of rs3798759 may be a risk factor for female patients with schizophrenia, and haplotypes C-A-G and C-G-G may be risk factors for schizophrenia.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Esquizofrenia
/
Haplotipos
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Secuencia de Bases
/
Estudios de Casos y Controles
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Factores Sexuales
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Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
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Receptor alfa de Estrógeno
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Alelos
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Frecuencia de los Genes
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2013
Tipo del documento:
Article