Relationship between gene polymorphism and haplotype of SLC6A2 promoter and blood-stasis pattern in patients with essential hypertension / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 458-462, 2010.
Article
en Zh
| WPRIM
| ID: wpr-231501
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the genetic variants of the norepinephrine transporter gene solute carrier family 6 member 2 (SLC6A2) and blood stasis pattern (BSP) in patients with essential hypertension (EH).</p><p><b>METHODS</b>DNA was extracted from the peripheral blood of 830 EH patients (532 were typed as BSP and 298 as non-BSS) and 512 persons with normal blood pressure (for control), to detect the polymorphisms of SLC6A2 promoter-3 and 2 by PCR-RFLP, and estimate the haplotype frequency adopting SHEsis program.</p><p><b>RESULTS</b>Chi2 partition showed that frequency of promoter-2-GG genotype in EH patients of BSP was lower than that in the EH patients of non-BSP and the normal control (P = 0.001); while that of promoter-3-GG/GA in the EH patients with severe BSP was the highest (P < 0.001). Logistic regression analysis showed that after the miscellaneous factors being rectified, with the reference category of EH-non-BSP, the relative odds ratio (OR) of promoter-2-GC/CC genotype for EH-BSP was 1.535 (95% CI: 1.094-2.155, P = 0.013); that of promoter-3-AG/GG genotype for EH with severe BSP was 1.925 (95% CI: 1.199-3.091, P = 0.007); while OR of G-C haplotype (promoter-3-promoter-2) for EH-BSP was 2.127 (95% CI: 1.202-3.765, P = 0.010), showing the strongest intensity.</p><p><b>CONCLUSION</b>SLC6A2 promoter-3-GA/GG genotype may be a susceptibility gene for patients of EH with severe BSP; promoter-2-GC/CC and G-C haplotype might be the susceptible factors to EH-BSP.</p>
Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Haplotipos
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Estudios de Casos y Controles
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Regiones Promotoras Genéticas
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Diagnóstico
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Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática
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Frecuencia de los Genes
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Genética
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Genotipo
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2010
Tipo del documento:
Article