Preparation and in vitro evaluation of ampelopsin-loaded nanomicelles / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 1054-1058, 2016.
Article
en Zh
| WPRIM
| ID: wpr-230037
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WPRO
ABSTRACT
To improve the solubility and antitumor activity of ampelopsin, ampelopsin-loaded nanomicelles from the mixture of pluronic F127 and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS1000) were prepared by film-thin hydration method, in order to optimize the process conditions and physicochemical properties. The antitumor activities against MCF-7 cells between ampelopsin and nanomicelles were compared by MTT method, respectively. The results showed that the optimal nanomicelles were round with the nanometric size of (22.6±0.5) nm, encapsulation efficiency rate of (80.42±1.13)%, and drug-loading rate of (4.41±0.26)%. The solubility of ampelopsin in mixed nanomicelles significantly increased by 16 times. In different release media, the mixed nanomicelles could release more than 90% of drug in 8 h, and showed stronger cytotoxicity and inhibition against MCF-7 cells (P<0.01). The mixed nanomicelles can be used as new drug delivery system of ampelopsin.
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WPRIM
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2016
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Article