The methylation locus and frequency pattern on p16 INK4a gene promoter CpG in epidermis of patients with psoriasis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 674-676, 2007.
Article
en Zh
| WPRIM
| ID: wpr-229847
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the CpG methylation locus and frequency pattern on p16 INK4a gene promoter in epidermis of p16 INK4a methylated patients with psoriasis vulgaris.</p><p><b>METHODS</b>The DNA specimens were obtained from epidermal lesion of 50 plaque psoriatic patients. Methylation specific PCR and DNA sequencing were used to detect the frequency and locus of methylation in p16 INK4a gene promoter region.</p><p><b>RESULTS</b>Approximately 50% CpG was methylated in p16 INK4a methylated patients, methylation was found in specifical locus of p16 INK4a gene promoter.</p><p><b>CONCLUSION</b>The distinct methylation pattern is showed on the p16 INK4a gene promoter region in patients with psoriasis.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Psoriasis
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Datos de Secuencia Molecular
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Secuencia de Bases
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Reacción en Cadena de la Polimerasa
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Alineación de Secuencia
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Regiones Promotoras Genéticas
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Islas de CpG
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Metilación de ADN
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Inhibidor p16 de la Quinasa Dependiente de Ciclina
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Proteína p14ARF Supresora de Tumor
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Article