A Case of Hypersensitivity Reaction Induced by Abacavir in an AIDS Patient / 대한내과학회지
Korean Journal of Medicine
; : 136-140, 2012.
Article
en Ko
| WPRIM
| ID: wpr-227526
Biblioteca responsable:
WPRO
ABSTRACT
Abacavir is a nucleoside reverse transcriptase inhibitor that is commonly used in HIV-infected patients. A well-known and potentially life-threatening side effect of abacavir is allergic hypersensitivity reaction. A screening test for the HLA-B*5701 allele is currently used to predict the risk of hypersensitivity reaction to abacavir. This test, however, may be less useful in Korea, because of the low prevalence of HLA-B*5701. A 52-year-old male with HIV infection was referred to our hospital because of suspected side-effects of antiviral agents and lymph node enlargement of the neck. He suffered from a fever, generalized edema, skin rash of the whole body, and difficulty breathing after starting antiviral agents. Suspected as a hypersensitivity reaction resulting from drug side-effects, prescription of abacavir was stopped. The patient subsequently recovered. The presence of the HLA-B*5701 allele was confirmed by polymerase chain reaction-sequencing based typing (PCR-SBT).
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Antivirales
/
Respiración
/
Didesoxinucleósidos
/
Antígenos HLA-B
/
Infecciones por VIH
/
Tamizaje Masivo
/
Prevalencia
/
ADN Polimerasa Dirigida por ARN
/
Edema
/
Alelos
Tipo de estudio:
Prevalence_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Medicine
Año:
2012
Tipo del documento:
Article