Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
Yonsei Medical Journal
; : 654-657, 2012.
Article
en En
| WPRIM
| ID: wpr-22414
Biblioteca responsable:
WPRO
ABSTRACT
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fagocitosis
/
Plata
/
Línea Celular
/
Supervivencia Celular
/
Interleucina-8
/
Endocitosis
/
Nanopartículas del Metal
/
Macrófagos
Límite:
Humans
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2012
Tipo del documento:
Article