Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level / 대한통증학회지
The Korean Journal of Pain
; : 113-117, 2005.
Article
en Ko
| WPRIM
| ID: wpr-215230
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea and vomiting. The aim of this study was to examine whether the analgesic effect of morphine is antagonized by serotonin 3 receptor antagonists at the spinal level. METHODS: Rats were implanted with lumbar intrathecal catheters. For nociception, a formalin solution (5%, 50microliter) was injected into the hind paw of male Sprague-Dawley rats. To determine whether the effect of intrathecal morphine was mediated via serotonin 3 receptors, serotonin 3 receptor antagonists were intrathecally administered 10 min prior to the morphine delivery. Following the formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min. RESULTS: Intrathecal morphine produced a dose-dependent suppression of the flinches in both phases during the formalin test. The analgesic action of morphine was not reversed by serotonin 3 receptor antagonists (LY-278, 584, ondansetron), which had little per se effect on the formalin-induced nociception. CONCLUSIONS: Spinal serotonin 3 receptors may not be involved in the analgesia of morphine on a nociceptive state evoked by a formalin stimulus.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Médula Espinal
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Vómitos
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Dimensión del Dolor
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Serotonina
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Ratas Sprague-Dawley
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Receptores de Serotonina 5-HT3
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Catéteres
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Nocicepción
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Formaldehído
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Analgesia
Límite:
Animals
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Humans
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Male
Idioma:
Ko
Revista:
The Korean Journal of Pain
Año:
2005
Tipo del documento:
Article