HPV Genotyping in Squamous Cell Carcinoma of Upper Aerodigestive Tract
Korean Journal of Pathology
; : 483-487, 2010.
Article
en En
| WPRIM
| ID: wpr-209652
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Smoking and alcohol consumption are the main risk factors for squamous cell carcinoma of the upper aerodigestive tract (SCCUAT). However, human papillomavirus (HPV) has been etiologically linked with tonsillar squamous cell carcinoma (TSCC). Therefore, we investigated the etiologic role of HPV in the context of SCCUAT in Korea. METHODS: Archival paraffin block samples from 136 cases previously diagnosed as SCCUAT were randomly selected. A commercial HPV DNA chip was used for HPV genotyping. RESULTS: One hundred and seventeen cases were available after checking beta-globin (47 cases of tonsil and 70 of non-tonsil). A HPV-positive result (HPV 16 and 18) occurred in 13 cases of SCCUAT, and 12 cases were tonsil (25.5%, 12/47). Among the 12 HPV-positive patients with TSCC, nine were non-smokers and non-drinkers. Most HPV-negative patients with TSCC had a history of alcohol drinking and smoking (32/35, 91.4%). HPV infection status was not significantly associated with histological grade, clinical stage, or survival in patients with TSCC. CONCLUSIONS: HPV infection was significantly higher in patients with TSCC among those with SCCUAT. HPV may be independent risk factor in development of TSCC, such as smoking and alcohol drinking.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Parafina
/
Humo
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Tonsila Palatina
/
Consumo de Bebidas Alcohólicas
/
Carcinoma de Células Escamosas
/
Fumar
/
Factores de Riesgo
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Globinas beta
/
Corea (Geográfico)
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Korean Journal of Pathology
Año:
2010
Tipo del documento:
Article