Sirolimus Conversion Efficacy for Graft Function Improvement and Histopathology in Renal Recipients with Mild to Moderate Renal Insufficiency
Journal of Korean Medical Science
; : 1069-1076, 2014.
Article
en En
| WPRIM
| ID: wpr-208226
Biblioteca responsable:
WPRO
ABSTRACT
This study was designed to evaluate whether sirolimus (SRL) conversion effectively improves renal function and histopathology in calcineurin inhibitor (CNI)-treated renal recipients with mild to moderate renal insufficiency. SRL conversion from CNI was performed in patients who underwent kidney transplantation from 6 months to 5 yr prior to screening. Forty-five patients were enrolled. The effect of SRL conversion on graft function was evaluated, and protocol biopsies were performed preconversion and 1 yr after conversion. Overall graft function after SRL conversion gradually improved, and the improvement in renal function was closely associated with the shorter duration of CNI exposure. When we divided the patients by the duration of CNI exposure, the patients with less than 1 yr of CNI exposure demonstrated significant improvement, but patients with a greater than 1 yr CNI exposure did not exhibit significant improvement. In contrast, protocol biopsies demonstrated no significant improvements in the modified "ah" score or other Banff scores after SRL conversion. Furthermore, the duration of CNI treatment prior to SRL conversion was not associated with histological findings 1 yr after SRL conversion. SRL conversion improved graft function in renal recipients with mild to moderate renal insufficiency, but this effect is not accompanied by histological improvement.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Índice de Severidad de la Enfermedad
/
Trasplante de Riñón
/
Resultado del Tratamiento
/
Sirolimus
/
Tolerancia al Trasplante
/
Sinergismo Farmacológico
/
Insuficiencia Renal
/
República de Corea
/
Inhibidores de la Calcineurina
/
Rechazo de Injerto
Tipo de estudio:
Guideline
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2014
Tipo del documento:
Article