Cellular and Systemic Interactions of Orientia tsutsugamushi with Mammalian Host
Journal of Bacteriology and Virology
; : 276-283, 2012.
Article
en Ko
| WPRIM
| ID: wpr-200677
Biblioteca responsable:
WPRO
ABSTRACT
Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi infection and one of main causes of febrile illness in the Asia-Pacific region. It has been estimated that one billion people are at risk and one million new cases arise each year in the endemic region. Despite of aggressive attempts to develop a prophylactic vaccine against scrub typhus during last several decades, all approaches have failed to generate long lasting immunity. In addition, little is known about the immunological pathogenesis of scrub typhus. In this review, we summarized recent findings of cellular and systemic interaction of O. tsutsugamushi with mammalian host, especially focusing on the molecular basis of intracellular invasion and immunological changes observed during the bacterial infection.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Orientia tsutsugamushi
/
Infecciones Bacterianas
/
Tifus por Ácaros
Idioma:
Ko
Revista:
Journal of Bacteriology and Virology
Año:
2012
Tipo del documento:
Article