Seroepidemiologic Survey of Varicella-Zoster Virus in Korean Adults Using Glycoprotein Enzyme Immuno Assay and Fluorescent Antibody to Membrane Antigen Test
Annals of Dermatology
; : 39-43, 2011.
Article
en En
| WPRIM
| ID: wpr-196212
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Herpes zoster (HZ) occurs mainly in the elderly and Korea is rapidly becoming an aging society. Therefore, it is important to know the immune status against varicella-zoster virus (VZV) in Korean adults to prevent the disease. OBJECTIVE: The aim of this study was to survey the immune status of Korean adults over 40 years of age against VZV. METHODS: Antibody titer was measured using a VaccZyme(TM) VZV glycoprotein enzyme immunoassay (gpEIA) (Binding Site, UK). Fluorescent antibody to membrane antigen (FAMA) test was performed to measure the seropositive rate. RESULTS: HZ incidence in the 214 adults enrolled in this study was 10.3%. The gpEIA geometric mean titer (GMT) was 490 mIU/ml and 90.2% of the subjects had a protective level of gpEIA antibody titer against varicella. The average gpEIA GMT of adults who previously had HZ was 1,122 mIU/ml, which was higher than the average gpEIA GMT of 457 mIU/ml in adults who had not had HZ. The FAMA positive rate was 98.6%. CONCLUSION: Most (90.2%) Korean adults > or =40-years-of-age have a protective level of gpEIA antibody against varicella and 98.6% were FAMA seropositive. The GMT of gpEIA antibody was significantly increased with age, and was higher in adults with a history of HZ.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Envejecimiento
/
Glicoproteínas
/
Estudios Seroepidemiológicos
/
Varicela
/
Incidencia
/
Técnicas para Inmunoenzimas
/
Herpesvirus Humano 3
/
Herpes Zóster
/
Corea (Geográfico)
/
Membranas
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Annals of Dermatology
Año:
2011
Tipo del documento:
Article