Clinical Usefulness of Human Immunodeficiency Virus(HIV)-1 p24 Antigen Testing / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 149-155, 1997.
Article
en Ko
| WPRIM
| ID: wpr-185764
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Recently some countries such as U.S.A. and Canada where human immunodeficiency virus(HIV) infection is rather prevalent, included HIV-1 p24 antigen test as a routine donor blood screening. This study was performed to evaluate the advantage of additional p24 antigen testing for the prevention of transfusion-associated AIDS infection in Korea. METHODS: Blood collected from 1726 volunteer blood donors, 16 HIV-positive patients, 39 sera from 4 commercial seroconversion panels, 15 sera included in low titer performance panel were tested with HIV-1 p24 Antigen ELISA Test System(Ortho Diagnostic Systems, U.S.A.). Anti-HIV antibody was also measured in parallel employing commercial kits produced by two world-famous companies. For some sera, western blot testing was additionally done. RESULTS: False-positive rate of p24 antigen testing was 0.06%. In 2 examples from 4 seroconversion panels, the p24 antigen test detected HIV infection 1-25 days and 11-47 days earlier than anti-HIV tests. CONCLUSION: Additional p24 antigen testing was found to have a potential to reduce transfusion-associated HIV infections. Including the p24 antigen testing as a routine donor screening should be considered if the number of transfusion-associated HIV infections continues to grow in Korea.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Donantes de Tejidos
/
Voluntarios
/
Donantes de Sangre
/
Canadá
/
Ensayo de Inmunoadsorción Enzimática
/
Infecciones por VIH
/
Tamizaje Masivo
/
Western Blotting
/
VIH-1
/
Selección de Donante
Tipo de estudio:
Screening_studies
Límite:
Humans
País/Región como asunto:
America do norte
/
Asia
Idioma:
Ko
Revista:
Korean Journal of Blood Transfusion
Año:
1997
Tipo del documento:
Article