Neuro-developmental Assessment of Patients with Transposition of the Great Arteries by Localized 1H-Magnetic Resonance Spectroscopy
Journal of the Korean Pediatric Society
; : 533-545, 2001.
Article
en Ko
| WPRIM
| ID: wpr-181284
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The purpose of this study was to evaluate the hemodynamic effect of transposition of the great arteries(TGA) on neuro-development by measuring the cerebral metabolites before and 1 year after open heart surgery(OHS) by localized in vivo 1H-magnetic resonance spectroscopy(1H- MRS) along with Bayley scales of infants development II(BSID II). METHODS: Full-term newborns(N=13) with TGA and intact ventricular septum were examined 1H-MRS before OHS. Follow-up MRS and neuro-developmental examination by BSID II were performed in 9 patients at 12 months of age. Normal newborns(N=22) and infants(N=13, ages=9- 36 months) were included for comparison. Image guided STEAM-spectra were obtained from the parietal white matter(PWM) and occipital gray matter(OGM) regions with proton brain examina tion(PROBE). All spectroscopic raw data were processed and the values of the NAA/Cr, Cho/Cr, mI/Cr and NAA/Cho ratios were calculated. RESULTS: The Values of NAA/Cr and NAA/Cho were lower in PWM and OGM, and Cho/Cr and mI/ Cr were higher in OGM from infants with TGA than from normal infants, suggesting that the abnor mal hemodynamics of TGA in fetal life may have influenced neuro-development. The follow-up MRS examinations conducted at 12 months also showed high Cho/Cr and low NAA/Cho in PWM. All abnor mal metabolite ratios from OGM in TGA newborns were normalized by 12 months. The results of BSID II showed relatively delayed mental development, especially language area than psychomotor development. CONCLUSION: The cerebral metabolism in infants with TGA has already been damaged prior to OHS and was not normalized by 12 months. However, the exact cause of the impaired metabolism is still not yet determined from this study; it may be due to the prenatal relative hypoxemia of the brain or OHS itself.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Arterias
/
Protones
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Análisis Espectral
/
Pesos y Medidas
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Encéfalo
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Espectroscopía de Resonancia Magnética
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Estudios de Seguimiento
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Tabique Interventricular
/
Rabeprazol
/
Corazón
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Humans
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Infant
/
Newborn
Idioma:
Ko
Revista:
Journal of the Korean Pediatric Society
Año:
2001
Tipo del documento:
Article