A Neuromedin B Receptor Blockade Inhibits the Growth of Human Oral Cancer Cells
International Journal of Oral Biology
; : 1-7, 2014.
Article
en Ko
| WPRIM
| ID: wpr-180774
Biblioteca responsable:
WPRO
ABSTRACT
Neuromedin B (NMB) acts as a growth factor or a morphogen and plays a role in cancer progression. Indeed, the NMB receptor (NMB-R) is overexpressed in different types of tumors. In our current study, we investigated the involvement of NMB-R in the proliferation of oral cancer cells. Human oral squamous cell carcinoma (SCC) and human oral cancer cells, SCC-25 cells were found to be NMB-R-positive. The NMB-R antagonist PD168368 inhibited the proliferation of SCC-25 cells and reduced their colony formation capacity. We also found that PD168368 induced the cell cycle arrest and apoptosis of SCC-25 cells in a dose-/time-dependent manner. Overall, this antitumor activity of PD168368 in human oral cancer cells suggests that NMB-R is a potential target for the future prevention and treatment of human cancers.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Apoptosis
/
Receptores de Bombesina
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Puntos de Control del Ciclo Celular
Límite:
Humans
Idioma:
Ko
Revista:
International Journal of Oral Biology
Año:
2014
Tipo del documento:
Article