Can Prostate-Specific Antigen Kinetics before Prostate Biopsy Predict the Malignant Potential of Prostate Cancer?
Yonsei Medical Journal
; : 1492-1496, 2015.
Article
en En
| WPRIM
| ID: wpr-177078
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE). MATERIALS AND METHODS: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level or =8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared. RESULTS: The group with a Gleason sum > or =8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups. CONCLUSION: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum > or =8 or the presence of extracapsular invasion.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
/
Próstata
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Prostatectomía
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Neoplasias de la Próstata
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Biopsia con Aguja
/
Cinética
/
Valor Predictivo de las Pruebas
/
Estudios Retrospectivos
/
Antígeno Prostático Específico
/
Carga Tumoral
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2015
Tipo del documento:
Article