Microbial Profile of the Stomach: Comparison between Normal Mucosa and Cancer Tissue in the Same Patient
Journal of Bacteriology and Virology
; : 162-169, 2014.
Article
en En
| WPRIM
| ID: wpr-163001
Biblioteca responsable:
WPRO
ABSTRACT
Gastric cancer is the third most common cancer and the third most frequent cause of cancer mortality in Asia. It is predicted that gastric cancer will remain an important cause of death at least during the next half century because of the increasing number of new cases in an aging population. However, little has been revealed about the role of gastric microbes and their reaction to gastric cancer. In this study, we identified differences in the microbial communities between gastric cancer and normal gastric mucosa by comparing the microbiomes of tissues from the same patients. The clustering analysis results showed different bacterial communities between normal gastric mucosa and gastric cancer. A comparison of bacterial communities at the species level revealed that Helicobacter pylori was significantly reduced in cancer tissue compared to that in normal gastric mucosa in the same patient. A comparison at the genus level showed that Propionibacterium spp., Staphylococcus spp., and Corynebacterium spp. had significantly reduced populations in cancer tissue, whereas Clostridium spp. and Prevotella spp. had significantly increased populations in cancer tissue.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Propionibacterium
/
Asia
/
Staphylococcus
/
Estómago
/
Neoplasias Gástricas
/
Envejecimiento
/
Mortalidad
/
Causas de Muerte
/
Helicobacter pylori
/
Clostridium
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Journal of Bacteriology and Virology
Año:
2014
Tipo del documento:
Article