Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer
Experimental & Molecular Medicine
; : e389-2017.
Article
en En
| WPRIM
| ID: wpr-158421
Biblioteca responsable:
WPRO
ABSTRACT
The endoplasmic reticulum (ER) is an important subcellular organelle that is involved in numerous activities required to achieve and maintain functional proteins in addition to its role in the biosynthesis of lipids and as a repository of intracellular Ca²⁺. The inability of the ER to cope with protein folding beyond its capacity causes disturbances that evoke ER stress. Cells possess molecular mechanisms aimed at clearing unwanted cargo from the ER lumen as an adaptive response, but failing to do so navigates the system towards cell death. This systemic approach is called the unfolded protein response. Aging insults cells through various perturbations in homeostasis that involve curtailing ER function by mitigating the expression of its resident chaperones and enzymes. Here the unfolded protein response (UPR) cannot protect the cell due to the weakening of its protective arm, which exacerbates imbalanced homeostasis. Aging predisposed breast malignancy activates the UPR, but tumor cells maneuver the mechanistic details of the UPR, favoring tumorigenesis and thereby eliciting a treacherous condition. Tumor cells exploit UPR pathways via crosstalk involving various signaling cascades that usher tumor cells to immortality. This review aims to present a collection of data that can delineate the missing links of molecular signatures between aging and breast cancer.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Brazo
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Mama
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Neoplasias de la Mama
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Envejecimiento
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Orgánulos
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Muerte Celular
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Pliegue de Proteína
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Retículo Endoplásmico
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Respuesta de Proteína Desplegada
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Carcinogénesis
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2017
Tipo del documento:
Article