One Korean Patient with a Family History of BRCA1-associated Ovarian Cancer
Journal of Genetic Medicine
; : 179-182, 2009.
Article
en En
| WPRIM
| ID: wpr-15580
Biblioteca responsable:
WPRO
ABSTRACT
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer. Among BRCA1- and BRCA2- mutation carriers, the average cumulative risks for ovarian cancer by age 70 years were 39% and 11%, respectively. There are other hereditary cancer syndromes such as Hereditary nonpolyposis colorectal cancer also confer a higher risk for developing ovarian cancer, but over 90% of all hereditary ovarian cancers are thought to be associated with BRCA1 or BRCA2 mutations. This report concerns a Korean woman diagnosed with ovarian cancer present with a family history of ovarian and various other cancers, in whom a germline BRCA1 mutation was identified and the same mutation was found in one of two daughters of her's. Since there could be more hereditary ovarian cancer patients in Korean than clinicians thought, both primary and secondary prevention of ovarian cancer based on family history and genetic information is important to reduce cancer incidence and mortality.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias Ováricas
/
Síndromes Neoplásicos Hereditarios
/
Mama
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Núcleo Familiar
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Neoplasias Colorrectales Hereditarias sin Poliposis
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Incidencia
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Mutación de Línea Germinal
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Prevención Secundaria
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Journal of Genetic Medicine
Año:
2009
Tipo del documento:
Article